Picking the right drug regimen for antiretroviral therapy (ART) for HIV patients can be a challenge. Healthcare providers must work with each patient to develop a treatment strategy that is both clinically sound and appropriate for that individual's needs, priorities, and circumstances of daily life. Characteristics of the regimens currently recommended by the DHHS Guidelines include virologic efficacy, a low pill burden, and fewer adverse effects than earlier regimens. However, not all patients will be able to take or tolerate all drugs. The patient's general understanding, readiness to commit to the regimen, and, for treatment-experienced patients, history of adherence to previous regimens must be considered when choosing ART.